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HU Credits:
3
Degree/Cycle:
1st degree (Bachelor)
Responsible Department:
Medicine
Semester:
2nd Semester
Teaching Languages:
Hebrew
Campus:
Ein Karem
Course/Module Coordinator:
Prof Baruch Minke
Coordinator Office Hours:
By appointment
Teaching Staff:
Prof Baruch Minke
Dr.
Mr.
Ms. Shaked Cohen
Mr. Omer Barkai
Ms.
Ms.
Ms.
Course/Module description:
physiology of excitable tissues, nerve, muscle, contractility and synaptic transmission.
Course/Module aims:
To provide an overview of the cellular, molecular and global neuronal processes underlying the functions of excitable tissues.
Learning outcomes - On successful completion of this module, students should be able to:
On successful completion of this module, students should be able to:
• Explain how the electrical activity of neurons is produced in biophysical terms.
• Apply biophysical principles to explain the function of neurons, muscles and sensory systems.
• Describe the mechanisms underlying neuronal function, synaptic transmission.
• Describe the signaling pathways which regulate activity of synapses, skeletal muscles in a state of health and some cases of disease.
• Select techniques suitable for the evaluation of cellular and molecular processes that account for the electrical activity of neurons, muscles and sensory cells as well as their basic functions.
Attendance requirements(%):
Tutorials (100%)
laboratories 100%
Teaching arrangement and method of instruction:
Lectures & Tutorials
Course/Module Content:
• Mechanisms of passive and active movement of ions across membranes.
• Hodgkin and Huxley model of channel gating.
• Physiology of axons, propagation of the action potential and molecular structure of ion channels.
• Physiology of skeletal muscles, mechanics, structure-function relationship, contractility, molecular mechanism of contraction and excitation contraction coupling.
• Cellular communication, synaptic transmission, pre and post synaptic processes, neurotransmitters, excitatory and inhibitory synapses.
Required Reading:
None
Additional Reading Material:
1. From Neuron to Brain by J.G. Nicholls, R. Martin, B. G. Wallace & P. A. Fuchs 4th edition Sinauer Associates Inc. Publisher
2. Principles of Neural
Science by E.R. Kandel, J.H. Schwartz and T.M. Jessell 5th edition McGraw‐HillNY
Course/Module evaluation:
End of year written/oral examination 85 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 0 %
Assignments 0 %
Reports 0 %
Research project 0 %
Quizzes 0 %
Other 15 %
laboratories
Additional information:
Participation in exercises is mandatory. Unjustified absences will subtract 2.5 points from the final grade.
Passing test grade is mandatory for weighting with laboratories grade.
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