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HU Credits:
2
Degree/Cycle:
2nd degree (Master)
Responsible Department:
Bio-Medical Sciences
Semester:
2nd Semester
Teaching Languages:
Hebrew
Campus:
Ein Karem
Course/Module Coordinator:
Prof Rachel Bar-Shavit
Coordinator Office Hours:
wednesday 10-12
Teaching Staff:
Prof Rachel Bar-Shavit,
Prof Zvika Granot
Course/Module description:
Molecular and cell biology of cell-cell and cell-ECM interactions. Structure and function of integrins, cadherins, selectins and immunoglobulins. Molecular mechanism of cell signaling: aspects of Ouside-in and Inside-out signals. Molecular aspects of physiological and pathological events that take place in vessel walls. Regulation of tumor development, metastatic spread and blood vessel growth. Biotechnological and clinical applications.
Course/Module aims:
- To understand structure and function of cell adhesion molecules
- Signals conveyed by ECM-cell cross-talk
- Development of primary tumors and metastatic spread
- Impact of tumor microenvironment on the tumor
Learning outcomes - On successful completion of this module, students should be able to:
To understand patho- and physiological aspects of cell ahesion molecules ( CAM).
Attendance requirements(%):
100%
Teaching arrangement and method of instruction:
Lectures given by teachers.
Seminars by students.
Course/Module Content:
1.Overview
2. Integrins
-3.ECM/Integrins
4. Cadherins
5. CAM and placenta implantation
6. Leukocyte adhesion
7. Implication to medicine
8. Seminars by students participants
Required Reading:
Essential Cell Biology (by:Alberts, Bray, Johnson, Lewis, raff, Roberts and Walter)
Chapter 15: cell communications
And chapter 19: Tissues
Or its parallel in Molecular Biology of the Cell
Additional Reading Material:
1.Xiaocong Pang , Xu He , Zhiwei Qiu , Hanxu Zhang , Ran Xie , Zhiyan Liu 1 2, Yanlun Gu , Nan Zhao , Qian Xiang , Yimin Cui. Targeting integrin pathways: mechanisms and advances in therapy. Signal Transduct Target Ther. 2023 Jan 2;8(1):1
2.Liu F, Wu Q, Dong Z, Liu K. Integrins in cancer: Emerging mechanisms and therapeutic opportunities.
Pharmacol Ther. 2023 Jul; 247:108458
3.Sulekha Suresh D, Guruvayoorappan C. Molecular principles of tissue invasion and metastasis. Am J Physiol Cell Physiol. 2023 May 1;324(5):C971-C991
4.Fu-Yang Lin, Jing Li, Yonghua Xie, Jianghai Zhu , Thi Thu Huong Nguyen, Yonghui Zhang, Jieqing Zhu, Timothy A Springer. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell. 2022 Sep 15;185(19):3533-3550.e27
5.Weiss F, Lauffenburger D, Friedl P.Towards targeting of shared mechanisms of cancer metastasis and therapy resistance.
Nat Rev Cancer. 2022 Mar; 22(3):157-173
6.Fagerholm SC Integrins in Health and Disease. N Engl J Med. 2022. PMID: 36170474
7.Mezu-Ndubuisi OJ, Maheshwari. The role of integrins in inflammation and angiogenesis.
Pediatr Res. 2021, May;89(7):1619-1626
8.Eun Jeong Park, Phyoe Kyawe Myint , Atsushi Ito , Michael G Appiah, Samuel Darkwah , Eiji Kawamoto, Motomu Shimaoka. Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin. Front Cell Dev Biol. 2020, Oct 26:8:588066, Review
9.Inbal Wortzel, Shani Dror, Candia M. Kenific, and David Lyden. Exosome-Mediated Metastasis: Communication from a Distance. Developmental Cell 2019, 49, May 6, 347-360
10.Kechagia JZ, Ivaska J, Roca-Cusachs P. Integrins as biomechanical sensors of the microenvironment. Nat Rev Mol Cell Biol. 2019 Aug;20(8):457-47
Grading Scheme :
Presentation / Poster Presentation / Lecture/ Seminar / Pro-seminar / Research proposal 80 %
Active Participation / Team Assignment 20 %
Additional information:
The course is open for MSc and PhD students
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