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HU Credits:
4.5
Degree/Cycle:
1st degree (Bachelor)
Responsible Department:
Bio-Medical Sciences
Semester:
2nd Semester
Teaching Languages:
Hebrew
Campus:
Ein Karem
Course/Module Coordinator:
Dr. Eitan Shaulian
Coordinator Office Hours:
Teaching Staff:
Dr. Eitan Shaulian,
Prof Oded Behar,
Prof Zvika Granot,
Prof Millet Treinin,
Ms. Rotem Tourgeman,
Ms. Joyce Kamar,
Mr. Anees Khatib,
Ms. Merav Gold
Course/Module description:
A basic course in cell biology. The course emphasizes the relationship between structure and function , and demonstrate the clinical implications
Course/Module aims:
The course provides basic concepts in cell biology
Learning outcomes - On successful completion of this module, students should be able to:
To know the structure of the eukaryotic cell
To understand intracellular processes
To understand the connection between cell structure and function
To understand the mechanisms controlling homeostasis cell proliferation and death and the processes occurring when some of these mechanisms are impaired
Attendance requirements(%):
Lecture: none
Workshop: 100%
Teaching arrangement and method of instruction:
Tutorial films and zoom meetings
Course/Module Content:
Introduction to the Cell:
The Evolution of the Cell: From Molecules to the First Cell; From Prokaryotes to Eukaryotes; From Single Cells to Multicellular Organisms
Small Molecules, Energy, and Biosynthesis: The Chemical Components of a Cell; Biological Order and Energy
Macromolecules- Structure, Shape, and Information: Molecular Recognition Processes; Nucleic Acids; Protein Structure; Proteins as Catalysts
Cell Membrane Structure: The Lipid Bilayer; Membrane Proteins Membrane Transport of Small Molecules and the Ionic Basis of Membrane Excitability: Principles of Membrane Transport; Carrier Proteins and Active Membrane Transport; Ion Channels and Electrical Properties of Membranes
Organelles:
Internal Organization of the Cell
The Compartmentalization of Higher Cells
Mitochondria; Peroxisomes; The Endoplasmic Reticulum; Golgi Apparatus; Lysosomes; Ribosomes
The Cytoskeleton
The Nature of the Cytoskeleton; Intermediate Filaments; Microtubules; Cilia and Centrioles; Actin Filaments; Actin-binding Proteins
The Cell Nucleus
Structure of the nucleus and its envelope; trafficking of proteins in and out of the nucleus; what is a gene; structure of the RNA; Chromosomal DNA and Its Packaging; The Global Structure of Chromosomes; Chromosome Replication; RNA Synthesis and RNA Processing; The Organization and Evolution of the Nuclear Genome; DNA Repair; DNA Replication; Genetic Recombination
Cell Cycle
The General Strategy of the Cell Cycle; The Early Embryonic Cell Cycle and the Role of MPF; Molecular Genetics of Cell-Cycle Control; Mitosis; Cytokinesis
Proteins: structure & production
From RNA to a protein; ribosomes and translation; RNA splicing
Endocytosis & Excocytosis
Transport from the ER through the Golgi Apparatus; Transport from the Trans Golgi Network to Lysosomes; Transport from the Plasma Membrane via Endosomes: Endocytosis; Transport from the Trans Golgi Network to the Cell Surface: Exocytosis; The Molecular Mechanisms of Vesicular Transport and the Maintenance of Compartmental Diversity
Cell Junctions
Cell Junctions; Cell-Cell Adhesion and their function in the multicellular organism
Signal Transduction pathways
Signaling via G-Protein-linked Cell-Surface Receptors; Signaling via Enzyme-linked Cell-Surface Receptors
Cell death
Apoptosis and programmed cell death
Molecular basis of Cancer
Cancer as a Microevolutionary Process; The Molecular Genetics of Cancer including Oncogenes and Tumor suppressor genes; Cancer is caused by numerous chmages in genes; novel theraputics- gene targeted therapy
Transport via the plasma membrane: Fick's laws, movement of particles via the lipid bilayer, channels and other transport mechanisms.
Diffusion: diffusion and Brownian motion, distance traversed via diffusion, diffusion via transporters.
Primary and secondary active transport: concentrations of ions in and out of cells, the sodium potassium ATPase and other pumps, symport and antiport.
Movement of water via the plasma membrane: forces affecting the movement of water (hydrostatic and osmotic pressures), osmotic pressure of solutes and their effects on the cell's volume, mechanisms for correcting the volume of cells, aquaporines, osmotic pressure and its effects on water's movement in the body.
Membrane potential and its effect on ion movement through the plasma membrane: the equilibrium potential for an ion (Nernst equation), governing membrane potential at rest and how resting potential is disrupted, resting potential and the ion's equilibrium potential and their effects on movement of ions.
Required Reading:
Alberts et al, Essential Cell Biology, 3nd edition, 2009
Additional Reading Material:
Course/Module evaluation:
End of year written/oral examination 100 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 0 %
Assignments 0 %
Reports 0 %
Research project 0 %
Quizzes 0 %
Other 0 %
workshop
Additional information:
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