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HU Credits:
9
Degree/Cycle:
1st degree (Bachelor)
Responsible Department:
medicine - basic studies
Semester:
1st Semester
Teaching Languages:
Hebrew
Campus:
Ein Karem
Course/Module Coordinator:
Dr. Maya Korem
Coordinator Office Hours:
No fixed hours. Available by email
Teaching Staff:
Prof Alon Warburg
Dr. Maya Korem
Prof Herve Bercovier
Prof Dana Wolf
Prof Amos Panet
Dr.
Dr. Jacob Strahilevitz
Dr. Shmuel Benenson
Prof Ron Dzikowski
Prof Ran Nir-Paz
Prof Rifat Safadi
Prof Allon Moses
Prof Colin Block
Dr. Hila Elinav
Prof Avi-Hai Hovav
Dr.
Dr. Oren Zimhony
Ms.
Ms. Libat Bar-Lev
Ms. Avigail Beryozkin
Ms. Hadas Masury
Mr. Raphael Serruya
Mr. Ibrahim Omar
Ms. Noa Roitenberg
Mr.
Course/Module description:
Medical microbiology is learned in a graded fashion. Basic introductory descriptions of bacteriology, virology, mycology, parasitology and antimicrobial agents lead into diagnostic methods and a consideration of infectious diseases by anatomical or functional systems. Special topics are dealt with as well, including deliberate use of microbial agents, the immunosuppressed host and healthcare associated infections.
Course/Module aims:
The course aims
1. to prepare medical students for their encounter, in their clinical studies and beyond, with infectious diseases and their management and prevention, their epidemiology and their public health significance.
2. to develop students' self-learning skills in the field for their obligations as life-long learners.
3. to engender the idea of team-work as a necessary element of the conduct of modern medicine.
Learning outcomes - On successful completion of this module, students should be able to:
1. To describe the general biological processes involved in disease production by microbial agents, host responses to these processes and the principles of antimicrobial agents.
2. To describe microbial agents of disease in terms of their classification, basic microbiological characteristics, pathogenesis, host responses, clinical manifestations, diagnosis, prevention and treatment of diseases they cause and their epidemiological and public health significance.
3. To apply the knowledge and skills gained in the course in the assessment, prevention and management of infectious diseases in patients and populations affected by these diseases.
4. To apply the skills developed for independent, self-directed learning in the identification and assessment of gaps or inadequacies in the knowledge gained from the course syllabus itself.
5. To acquire and apply the necessary knowledge and skills to fill such gaps in a reliable and safe fashion.
Attendance requirements(%):
In general, the Hebrew University Rules require attendance at all teaching activities. In this course, for purposes of grading, attendance is compulsory for the laboratory module
Teaching arrangement and method of instruction:
Large group components: lectures, labs, case workshops*, reading assignment* discussions. Small group activities: lectures prepared by the small groups and delivered to the whole class. Approximately 15% of the available time is devoted to independent study.
*Kahoot is used in these sessions to enhance student engagement.
Course/Module Content:
Introductory Section:
• Overview of microbes and other parasites in disease
• The bacteria: bacterial structure, growth, genetics and genomics
• Introduction to antibacterial drugs and their cellular targets
• Normal microbiota & introduction to host-parasite relationships; the human microbiome
• Innate and adaptive immunity in infectious diseases; the complex relationship between man and his residents; immunization
• Bacterial pathogenesis
• The viruses: classification, structure and replication
• Viruses: pathogenesis, epidemiology and transmission
• Introduction to fungi of medical importance
• Introduction to parasitology – the protozoa and arthropods of medical importance
• Introduction to parasitology – the helminths (worms (
• Antibiotics: mechanisms of action and resistance
• Antibacterial therapy: pharmacology and special aspects of resistance
• Antifungal agents
• Antiparasitic agents
• Disinfection and sterilization
• Approach to the diagnosis of bacterial infections and preparation for the labs
• Introduction to Clinical Virology and approach to diagnosis of viral infections
• Laboratories: 6 hours of “wet” laboratories outlining the classical process of diagnostic clinical microbiology, including
- Gram staining (gingival swabs(
- Nasal carriage of Staphylococcus aureus: culture and identification; calculation of carriage rate; presented in scenario of outbreak investigation.
- Quantitative culture of simulated urine: 3 organisms; plating for enumeration, identification and susceptibility testing
- Lab reports designed to simulate reports to physicians submitted and graded
Systems Section:
• Skin and soft tissue, bone & joint infections bacterial & fungal
• Staphylococci and streptococci
• Viral diseases with skin manifestations; childhood viral infections
• Herpes viruses
• Cardiovascular and bloodstream infections
• Urinary tract infections
• Bacteriology of common urinary pathogens
• Sexually transmitted infections (including HIV/AIDS)
• Respiratory tract infections
• Tuberculosis
• Respiratory viruses
• Student lectures: the topics change from year to year
• CNS infections: bacterial and fungal
• CNS infections: viral
• Obstetric and perinatal infections
• GIT: gastroenteritis, Helicobacter infection
• GIT: hepatitis
• GIT: parasitic diseases
• Vector borne diseases: malaria
• Vector borne diseases and multisystem bacterial zoonoses
• Student lectures: bartonellosis; rickettsiosis
• Viral zoonoses and vector-borne diseases
• Microbes as weapons
• Student lectures: botulism; smallpox
• The immune compromised host
infections in the immune compromised host
• Introduction to vaccination
Reading assignments (basic knowledge to be read and prepared for 1h plenum interactive discussion(
Learning a new language – bacteria
Learning a new language – antibiotics
Case Workshops (2-4 cases with questions; guided and independent reading; 2h plenum discussion with audience response system to promote student engagement):
Antimicrobial resistance Antibiotic resistance
“Flesh-eating bacteria”
Sexually transmitted infections/HIV
Bacterial toxins
Parasites
Required Reading:
Goering R et al, Mims’ Medical Microbiology 5th edition, available on line through the library (ClinicalKey)
Murray PR et al., Medical Microbiology 7th edition, available on line through the library (ClinicalKey)
Additional Reading Material:
There are several well known medical microbiology texts available on line from different services. In addition, well known texts in infectious diseases, pediatrics and internal medicine are suggested as supplementary reading depending on topics and teacher preferences. Published research and review papers and other resources are prescribed for the various assignments and case workshops. These are changed or updated quite frequently. Most are available on line
Grading Scheme :
Additional information:
The components of the final grade may change according to the actual number of assignments and/or reports.
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