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HU Credits:
3
Degree/Cycle:
2nd degree (Master)
Responsible Department:
Agroecology & Plant Health
Semester:
1st Semester
Teaching Languages:
English
Campus:
Rehovot
Course/Module Coordinator:
Prof Edouard Jurkevitch
Coordinator Office Hours:
Wednesday 11:15-13:00
Teaching Staff:
Prof Edouard Jurkevitch,
Dr. Assaf Levy
Course/Module description:
Through the examination of cell physiology, understand how bacteria adapt to their surroundings, and shape the environment.
Course/Module aims:
The course will cover a number of topics in microbial physiology with the aim of leading the students to appreciate the breath of the physiological diversity in prokaryotes and their adaptations to their environment. There is large reliance on understanding molecular methods.
Learning outcomes - On successful completion of this module, students should be able to:
Being able to link cellular and physiological processes to microbial activities and outcomes in the environment.
Attendance requirements(%):
compulsory
Teaching arrangement and method of instruction:
lectures, discussions on articles, active participation to class, presentation, within semester short controls
Course/Module Content:
Lecture 1. Physiology and ecology: two sides of microbial life; Bacterial evolution, including types of selection; mutations; HGT; co-evolution. EJ, AL
Lecture 2. Multicellular signaling in bacteria: quorum sensing; Single cell signaling: two component systems; secondary messengers. Paper 1. EJ
Lecture 3. Biofilms. Dr. Ilana Kolodkin-Gal, Weizmann Institute, Invited speaker. Paper 2.
Lecture 4. Diauxic growth; catabolite repression and stochasticity; reserve materials. Paper 3. EJ.
Lecture 5. Control 1. Adaptation to stress: the stringent response and starvation. Paper 4. EJ.
Lecture 6. Replication and division – the cell cycle: E. coli: a model or a snapshot? Alternative cell cycles. Paper 5. EJ.
Lecture 7. Secretion systems, effectors, and their functions. AL. Paper 6
Lecture 8. Microbial toxins; antibiotic resistance and persistence. Paper 7. AL.
Lecture 9. Uptake systems: passive, active uptake; Mechanisms; Integration in signaling systems. Paper 8. EJ.
Lecture 10. Control 2. Bacterial interaction with phages: CRISPR, abortive infection, restriction enzymes, and others. Paper 9. AL.
Lecture 11. Motility - flagellum, twitching, swarming, gliding. Paper 10. AL.
Lecture 12. Symbiosis and metabolic integration: from the origin of eukaryotes to modern taxa. Paper 11. EJ.
Lecture 13. The strange case of predatory bacteria or integrating systems (survival, cell cycleTCS/cdGMP/metabolism) Paper 12. EJ.
Lecture 14. Control 3. Remaining papers. General discussion (compulsory). AL, EJ.
Required Reading:
Will be given during class
Additional Reading Material:
Madigan, M.T, Martinko, J.M., and J. Parker. Brock’s Biology of Microorganisms.
Moat, A.G., and J.W. Foster. Microbial Physiology.
The Prokaryotes, eds Dworkin, M., Flakow, S., Rosenberg, E., Schleifer, K.H. & Stackebrandt E. (Springer-Verlag, New York, 2000).
Grading Scheme :
Additional information:
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