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HU Credits:
2
Degree/Cycle:
2nd degree (Master)
Responsible Department:
Biochemistry, Food Science and Nutrition
Semester:
2nd Semester
Teaching Languages:
English
Campus:
Rehovot
Course/Module Coordinator:
Prof. Masha Niv
http://departments.agri.huji.ac.il/biochemfoodsci722/teachers/niv_masha/lab/
Coordinator Office Hours:
by email appointment
Teaching Staff:
Course/Module description:
The course will be given in English. The target audience is MSc and PHD students interested in GPCRs. Particular emphasis will be given to structural aspects and practicing critical reading and summarizing of scientific papers
Course/Module aims:
Practice writing scientific review (as in refereeing a paper for a journal)
Learn to visualize GPCR structures and be able to identify (in 3D) regions of interest (interactions, ligand binding etc.)
Learning outcomes - On successful completion of this module, students should be able to:
List the main milestones in GPCR structural discovery
Find, download and visualize the structure of GPCR of interest
Obtain and visualize a structure or a model of GPCR of interest
Contribute new information to a wiki page of receptor of interest
Attendance requirements(%):
mandatory
Teaching arrangement and method of instruction:
Interactive and projects-based, on campus
Course/Module Content:
• Families A, B and C of GPCRs and main characteristics of GPCR structure, GPCRs in drug discovery
• Main aspects of GPCR structures
• Orthosteric vs allosteric binding sites, coupling to G-proteins, biased signaling
• Taste GPCRs
• Melanocortin receptors
Required Reading:
Papers will be available via moodle site of the course
Additional Reading Material:
Relevant podcasts, such as DrGPCR
Course/Module evaluation:
End of year written/oral examination 0 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 0 %
Assignments 0 %
Reports 35 %
Research project 50 %
Quizzes 15 %
Other 0 %
Additional information:
Please email Prof. Niv if you are interested to join the course
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