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HU Credits:
4
Degree/Cycle:
2nd degree (Master)
Responsible Department:
Chemistry
Semester:
2nd Semester
Teaching Languages:
English
Campus:
E. Safra
Course/Module Coordinator:
Dr. Ori Gidron
Coordinator Office Hours:
By appointment
Teaching Staff:
Dr. ori gidron
Course/Module description:
Three main topics are taught in the course:
1. Supramolecular Chemistry: History, basics concepts, supramolecular interactions, different systems (host-guest systems, helicates, catenanes, rotaxenes and more), optional material.
2. Symmetry in organic chemistry and its influence on the characteristics and reactivity of molecules.
3. Pericyclic reactions and understanding their mechanisms through molecular orbitals analysis.
Course/Module aims:
See Learning Outcomes.
Learning outcomes - On successful completion of this module, students should be able to:
Basic knowledge of concepts in supramolecular chemistry
Distinguish between different stereoisomers
Analyze the symmetry of a molecule and its influence on the nature of the molecule
Identify the mechanisms of pericyclic reactions
Attendance requirements(%):
None
Teaching arrangement and method of instruction:
Lecture and exercise
Course/Module Content:
Supramolecular Chemistry: History, basics concepts, supramolecular interactions, different systems (host-guest systems, helicates, catenanes, rotaxenes and more), optional material.
Stereochemistry: isometry and symmetry, generalization of the concept of chirality, point group symmetry, isomer classification, stereotopy and its expression in reactivity and in NMR, anisogamy.
Stereochemistry of pericyclic reactions: molecular orbitals in conjugated molecules, Woodward-Hoffman rules and frontier orbitals theory, electrocyclic reactions (ring opening and closing), sigmatropic rearrangements and cycloadditions. Generalization of the concept of aromaticity. Substituent effects on Diels-Alder reaction. Synthetic applications of pericyclic reactions.
Required Reading:
None
Additional Reading Material:
Core Concepts in Supramolecular Chemistry and Nanochemistry / Steed, Turner and Wallace: Online Access
Supramolecular Chemistry from Molecules to Nanomaterials / Gale and Steed: Online Access
Molecular Orbitals and Organic Chemical Reactions, Student Edition / Fleming: Online Access
Modern Physical Organic Chemistry / Anslyn and Dougherty QD 476 A57 2006 (4 copies)
Basic Organic Stereochemistry / Eliel, Wilen & Doyle: QD 481 E44 (1 copy)
Mechanism and Theory in Organic Chemistry / Lowry & Richardson: QD 476 L68 (2 copies (diff.
ed.))
Organic Reactions and Orbital Symmetry / Gilchrist & Storr: QD 476 G54 (2 copies (diff. ed.))
Frontier Orbitals and Organic Chemical Reactions / Fleming: QD 461 F53 (1 copy)
Course/Module evaluation:
End of year written/oral examination 70 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 15 %
Assignments 15 %
Reports 0 %
Research project 0 %
Quizzes 0 %
Other 0 %
Additional information:
At least 5 assignments should be submitted and pass with a grade of 6 and above. The assignment grade will be calculated as the average of the highest scoring 5 passing assignments (15% of the final grade).
Submission assignment of a report based on an article in the field of supramolecular chemistry constitutes 15% of the final grade.
The course is open for students from the School of Pharmacy.
The course is delivered in English.
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