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Syllabus Neuropsychology: Substrates and Mechanisms B - 51720
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Last update 10-03-2022
HU Credits: 3

Degree/Cycle: 2nd degree (Master)

Responsible Department: Psychology

Semester: 2nd Semester

Teaching Languages: Hebrew

Campus: Mt. Scopus

Course/Module Coordinator: Prof Eli Wertman

Coordinator Email: eli@merhav-clinic.co.il

Coordinator Office Hours:

Teaching Staff:
Prof Eli Wertman

Course/Module description:
- The course will include:
- Frontal lectures of the above principles.
- Presentations of selected case studies from the literature (e.g., proper name
anomia, thalamic thought disorder, etc.) that express the above principles. All
presentation of case studies will be held by the students under the guidance of
Prof. Wertman.
- For each class, students will receive mandatory and suggested reading material. Some of the reading will address specifically the case study to be presented in the class.
- The lessons will include innovative teaching components:
- Connections to international sites related to the course’s syllabus.
- Guiding students to search for and present innovative hypotheses for clinical research.
- In-depth analysis of case studies according to the literature and the knowledge acquired in the course. As a final test – a specific case will be assigned for each student, in relation to the student’s area of interest and under the advice of Prof. Wertman.

Course/Module aims:
To expose the students to state-of-the-art clinical neuropsychological models and algorithms of cognitive, emotional and conscious processes. Specifically, we will discuss:
- The developmental stages of various observed behaviors from a clinical and computational perspective;
- The accumulative clinical evidence from Lesions in patients and animals, functional neuroimaging and evolution studies;
- The synthesis various fields of knowledge and research on normal behavior.
And to describe the functional neuroanatomy of the above behaviors in light of the accumulated and most recent cortical parcellation, subcortical nuclei, cerebellum and white matter studies.

Learning outcomes - On successful completion of this module, students should be able to:
- Upon completion of the course the student will be able:
- To integrate different behavioral levels: focal- Macro-Micro, Network and Systemic.
- To determine critical stages for the onset of behavior by connecting clinical symptomathology, functional imaging findings and lesions studies, while considering cerebral biological constraints, that allow separation between different components of behavior.
- To present critical research questions that rely on the above connection.
- To develop clinical neuropsychological research.
- To diagnose neuropsychological impairments and plan rehabilitative treatment.

Attendance requirements(%):

Teaching arrangement and method of instruction:

Course/Module Content:
- Topics will include:
- Basic principles of localization in the brain – demonstrated by selected case studies.
- Algorithm model of clinical representation for the developmental stages of cognitive behavior.
- The functional-neuroanatomical perspective – from early stages of Broca, Wernicke to BOLD MRI.
- Cortical parcellation -from Brodmann and Vogt & Vogt to this day including Mesulam and Pandya & Selzer’s model.
- Cortical parcellation – non-observer dependent (cytoarchitecture, myeloarchitecture, neurochemical cytoarchitecture, Immunological cytoarchitecture, multimodal cytoarchitecture). Including the latest understanding of the structure and function of the Broca area.
- Functional-neuroanatomy of subcortical regions – Thalamus, Basal ganglia and Cerebellum.
- The visual cortex – its systems and connections from a functional-neuroanatomical perspective.
- Subjective experience – a model for cortical connections. Including Felman and Barbas models and the clinical significance of Baysian analysis and Interoceptive predictions.
- Functional integration – System networks. Including the normal and abnormal functioning of the saliency network, the default network, and the executive network.
- Language functions:
- Wernicke-Lichtheim-Geschwind’s model – the basic apathy language disorder syndromes; the need to revise the model.
- Symptoms mapping:
- Spontaneous speech components: fluency, prosody, grammar.
- Neuroanatomy – Including Frontal Aslant Tract, subcortical components.
- Word finding processes- Stages and functional neuroanatomy:
- The two-stage model:
- The semantic and phonological components.
- The clinical-neuropsychological profile of semantic and phonological disorders.
- Levelt model – Components and localization.
- Apraxia of speech – phonology of word production mechanisms.
- Systems for word perception: basic model (according to Fredericci); Mesulam Interpretation.
- An integrative clinical-neuropsychological model for the perception and production of words:
- Ellis & Young model.
- Characteristics for phonological performance: input / output lexicon (including deficit properties).
- Dual-route model of language:
- Hickok & Poeppel’s model for dorsal-ventral word processing.
- DeWitt & Rauschecker: Phoneme, word, phrase and sentence recognition in the ventral system.
- Bornkessel-Schlesewsky’s model for dorsal-ventral sentence processing.
- Systemic Deficits – Progressive aphasia syndromes: non-fluent and semantic aphasia.
- Hickok’s Model -The Hierarchical State Feedback Control (HSFC).
- Additional subjects:
- Neuropsychology of emotion.
- Clinical presentation and taxonomy of social cognition.
- Neuropsychology of aging processes.
- Dementia syndromes and Mild Cognitive Impairment:
- Alzheimer's disease – up-to-date pathophysiology and clinical neuropsychological manifestation.
- Typical neuropsychology of common dementia syndromes in elderly patients.

Required Reading:
see Moodle

Additional Reading Material:

Course/Module evaluation:
End of year written/oral examination 0 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 0 %
Assignments 0 %
Reports 0 %
Research project 0 %
Quizzes 0 %
Other 100 %
see below

Additional information:
 
Students needing academic accommodations based on a disability should contact the Center for Diagnosis and Support of Students with Learning Disabilities, or the Office for Students with Disabilities, as early as possible, to discuss and coordinate accommodations, based on relevant documentation.
For further information, please visit the site of the Dean of Students Office.
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