HU Credits: 4

Degree/Cycle: 1st degree (Bachelor)

Responsible Department: School of Pharmacy

Semester: 1st Semester

Teaching Languages: Hebrew

Campus: Ein Karem

Course/Module Coordinator: Dr. Dmitry Tsvelikhovsky

Coordinator Email: dmitryt@ekmd.huji.ac.il

Coordinator Office Hours: In coordination with a lecturer

Teaching Staff:
Prof Dmitry Tsvelikhovsky
Mr. David Lankri

Course/Module description:
The course provides students with basic knowledge in organic chemistry. The course includes terminology methods, the properties and important reactions of families with the following functional groups: alkanes, alkenes and Alkynes, Halo-alkanes, aromatic systems, alcohols, ethers, aldehydes and ketones.

Course/Module aims:
The course provides the students with basic knowledge of organic chemistry that will enable them to cope with understanding the synthesis concepts

Learning outcomes - On successful completion of this module, students should be able to:
On successful completion of this module, students should be able to: 1) Identify functional groups and remember their most important reactions. 2) Examine an organic molecule and construct its systematic name. 3) Suggest reagents and plan a practical way to synthesize desired organic molecules.

Attendance requirements(%):
None

Teaching arrangement and method of instruction: 3 hours lecture and one hour exercise

Course/Module Content:
1. Reactions of Alcohols, Ethers, Epoxides and Thiols
- Nucleophilic substitution reactions: forming Alkyl halides
- Elimination reactions: Dehydration
- Oxidation
- Reactions of ethers and epoxides
- Thiols

2. Organometallic Compounds

3. Reactions of Aldehydes and Ketones
- Nomenclature of aldehydes and ketones
- Structures
- Physical properties
- Relative reactivity of carbonyl compounds
- Reaction with nucleophiles

4. Reactions at the -Carbon of Carbonyl Compounds
- Acidity of an -Hydrogens
- Keto-Enol Tautomerism
- Halogenation of the -Carbon of Aldehydes and Ketones
- Enolate ion
- Alkylation of the -Carbon of Aldehydes and Ketones
- Enamines
- Michael Reactions
- Aldol addition
- Claisen Condensation

5. Reactions of Carboxylic Acids and Carboxylic Derivatives
- Nomenclature
- Structures
- Physical properties
- Relative reactivity of acids and derivatives
- Nucleophilic additions-elimination reactions
- Acyl chlorides
- Esters
- Hydrolysis and Esterification

6. Aromatic compounds
- Nomenclature
- Reactions

7. Dienes
- Nomenclature
- Reactions

Required Reading:
Textbook-Paula Yurkanis Bruice (updated version)

Additional Reading Material:
-

Course/Module evaluation:
End of year written/oral examination 100 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 0 %
Assignments 0 %
Reports 0 %
Research project 0 %
Quizzes 0 %
Other 0 %

Additional information:
The obligation to submit 80% of the exercises.